Is there a better way to write nested if statements in python?

Is there a more pythonic way to do nested if else statements than this one:

def convert_what(numeral_sys_1, numeral_sys_2):

    if numeral_sys_1 == numeral_sys_2:      
        return 0
    elif numeral_sys_1 == "Hexadecimal":
        if numeral_sys_2 == "Decimal":
            return 1
        elif numeral_sys_2 == "Binary":
            return 2
    elif numeral_sys_1 == "Decimal":
        if numeral_sys_2 == "Hexadecimal":
            return 4
        elif numeral_sys_2 == "Binary":
            return 6
    elif numeral_sys_1 == "Binary":
        if numeral_sys_2 == "Hexadecimal":
            return 5
        elif numeral_sys_2 == "Decimal":
            return 3
    else:
        return 0

This script is a part of a simple converter.