Smarter than If Else

I'm trying to do a switch (per say) of commands.

if 'Who' in line.split()[:3]:
    Who(line)   
elif 'Where' in line.split()[:3]:
    Where(line)
elif 'What' in line.split()[:3]:
    What(line)
elif 'When' in line.split()[:3]:
    When(line)
elif 'How' in line.split()[:3]:
    How(line)
elif "Make" in line.split()[:3]:
    Make(line)
elif "Can You" in line.split()[:3]:
    CY(line)
else:
    print("OK")

So the explanation. If Who, whatWhat...etc are in the first 3 words of the command then it executes the corresponding function. I just want to know if there is a smarter way to do this other than a lot of if,elif and else?